PK/PD Studies in Drug Discovery and Development
Duration : 60 Minutes
Dr. Stefano Persiani,
Dr. Stefano Persiani is currently Director of Translational Sciences and Pharmacokinetics at Rottapharm Biotech, Italy. He graduated in Pharmacy at the University of Milan, Italy and completed a Post-Doctoral fellowship in the Department of Pathology of the University of Pittsburgh School of Medic Read more
The webinar reviews the general concepts and basic elements of pharmacokinetics, pharmacodynamics, and their correlation. The use of PK/PD for dose selection during drug development will be described also with the presentation of a case study. The use of PK/PD will be described for the evaluation of both drug efficacy and safety. This will illustrate how the model-based drug development and, in particular, PK/PD studies, can facilitate knowledge management and decision making to streamline drug discovery and development and to reduce the attrition rate.
Course Objectives:
An effective evaluation of the PK PD and PKPD correlation is critical during drug discovery and development from proper dose and patient selection. The course will describe how the pharmacological (pharmacokinetic and pharmacodynamic) profile of a drug under development should be assessed to streamline the whole program. This applies to both wanted and unwanted (adverse) pharmacological effects during both pre and clinical development. The objectives of the course are to cover and explain all these aspects.
Why Should You Attend:
PK/PD studies construct, validate, and utilize disease models, drug exposure-response models, and pharmacometrics models to facilitate drug development. PK/PD studies offer great support to learn and confirm the key characteristics of new molecular entities in a quantitative manner. This provides evidence for optimizing drug development plans and enabling critical decision-making. Drug development without PK/PD modeling is considered at a higher risk of failure.
Course Outline:
• Absorption
• Distribution
• Metabolism
• Excretion
• Drug action
• Dose-response relationship
• Selectivity
• Therapeutic window
• Biomarkers
• Variation in response
• Hysteresis
• Case study
What You Get:
• Training Materials
• Live Q&A Session with our Expert
• Participation Certificate
• Access to Signup Community (Optional)
• Reward Points
Who Will Benefit:
• Project managers
• Pre-clinical and clinical pharmacologists
• Regulatory affairs
• Clinical research associates
• Drug discovery scientists
Please reach us at 1-888-844-8963 for any further assistance or if you wish to register
